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A sequence within exon 23 beginning with nucleotide 51 was replaced with the corresponding human cDNA encoding the C terminus of the gene and a stop codon. A loxP flanked neo was inserted into intron 23 and subsequently deleted via transient cre expression, leaving a single loxP site. Immunoprecipitation and Western blotting confirmed successful targeting and the presence of a chimeric mouse-human protein in mutants. (J:95855)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
