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A 36,241 bp genomic fragment spanning exons 18 - 31 was replaced with a PGK-neo cassette via homologous recombination. This resulted in removal of part of the IQ2 and all of the IQ3, IQ4, and GRD motifs. QRT-PCR confirmed the absence of transcript in hepatocytes and immunoblot analysis confirmed the absence of protein in liver, spleen, heart, and kidney lysates. Only in the liver was a modest increase in Iqgap1 expression detected. QRT-PCR analysis did not detect any change in F2rl2 (coding sequence contained within intron 13 of Iqgap2) expression. (J:132670)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
