A neomycin resistance gene flanked by loxP sites was inserted into intron 1 and a third loxP site was introduced into exon 2. Crossing with EIIa-cre mice resulted in the excision of the neo, leaving exon 2 flanked with loxP sites. (J:94911)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count