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A tet casette, containing tTA protein coding sequence, floxed neo coding sequence and tet operator/CMV promoter, was inserted into the 5' UTR of the SK3 gene 42 nt 5' of the initiator MET. Administration of doxycycline to homozygous tet anmials results in knockout of SK3 expression. In the absence of tet or dox, SK3 protein is overexpressed 3-5 fold over WT. (J:95064)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
