A fragment of sequence containing the ORF in exons 1 and 2 was replaced with a lacZ-PGK-neo cassette. Northern blot of mutant brains indicated a lack of Nkx6-2 transcript, however, two signals were observed that hybridized to a lacZ probe. X-gal staining demonstrated lacZ was expressed prenatally in neurons and postnatally in oligodendrocytes of mutant embryos. (J:94807)
Basic Information
(129X1/SvJ x 129S1/Sv)F1-Kitl+
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count