LoxP sites were inserted to flank the promoter and exon 1, the region containing key regulatory elements important for promoter activity as well as many of the DNA-binding and dimerization residues. (J:94725, J:99232)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count