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A dominant-negative murine Fgf receptor derived from the Ffgr1 splice variant IIIc was flanked by enhancer sequences from a rabbit Beta globin intron and polyA sequence from the human growth hormone gene. This construct was then cloned downstream of the Tyrosinase related protein-1 (Tyrp1) promoter. A high degree of transgene expression was detected in the retinal pigment epithelium by E10.5, but was not detected in the melanocytic lineage prior to cells becoming fully differentiated and pigmented. Eyes showed morphological abnormalities and a gross reduction in size. (J:64993)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
