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This targeted mutation deletes a 6-kilobase genomic DNA segment containing hs3b (Rr155) and hs4 (Rr156), the two most distant of four 3' transcriptional enhancers residing within the approximately 26 kilobase locus control region downstream of the Igh complex (3'RR or Rr152). The original targeting event replaced hs3b and hsb4 with a loxP-flanked neomycin resistance gene cassette. Crossing of chimeric founder mice with mice expressing Cre recombinase under control of the EIIa promoter yielded progeny in which the neo cassette was deleted in the germline. (J:71300)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
