This targeted mutation substitutes a 6-kilobase genomic DNA segment containing hs3b (Rr155) and hs4 (Rr156), the two most distant of four 3' transcriptional enhancers residing within the approximately 26 kb locus control region downstream of the Igh complex, with a loxP-flanked neomycin resistance gene cassette. (J:71300)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
129P2/OlaHsd
Targeted
Intragenic deletion
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1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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