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A deletion between Cops3 and Gid4 (previously, 4933439F18Rik) was engineered in ES cells by insertion of complementary partial Hprt-loxP constructs at each site. Insertion at Cops3 was specifically targeted whereas insertion in intron 3 of Gid4 was a random insertion brought about using a V15 retrovirus. Cre recombinase actived deleted the intervening region and reconstructed the Hprt minigene for selection purposes. Two additional, phenotypically identical, deletions were created in which the loxP-Hprt partial gene was inserted in intron 5 of Gid4 (MGI:3521943 and MGI:3521944). (J:94405)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
