Gucy2d^tm1Sdm

An IRES-Mapt-lacZ reporter with a floxed neo cassette was inserted between exon 2 and 3. RT-PCR confirmed the lack of transcription from the null allele. LacZ expression was confirmed by immunohistochemistry in a small number of main olfactory epithelium consistent with the small number of Gucy2d+ neurons previously reported. Cre-mediated recombination removed the floxed neo cassette. (J:124965)