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A human papilloma virus 16 (HPV16) genomic fragment (nt79-883) encompassing both the E6 and E7 genes was cloned between the human KRT14 promoter and polyA sequences. Only E6 is expressed due to the presence of a translation termination linker in the N-terminal region of the E7 gene. This line was estimated by Southern blot analysis to carry approximately 15 copies of the transgene. In situ hybridization demonstrates expession of E6 mRNA in the epidermis and also in the dermis, but confined largely to hair follicles in the latter. (J:55965)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
