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This transgene contains a HPV16 fragment (nt79-883) encompassing both the E6 and E7 genes along with promoter, 3' UTR and polyA sequences from human KRT14. Only E7 is expressed due to the presence of a translation termination linker in the N terminal region of the E6 gene. Transgene expression is targeted toward epithelial tissues. Mice derived from this founder line had 7-8 copies of the transgene. (J:86018)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
