The last 4 exons containing the C-terminal catalytic center were flanked with loxP sites and an IRES-lacZ cassette inserted such that after cre mediated recombination beta-galactosidase expression is controlled by the endogenous promoter. (J:94136)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count