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A loxP site flanked neomycin resistance gene cassette replaced a 1.9 kb section containing DNase I hypersensitivity site IV (HS IV), an Il4 silencer located between Il4 and Kif3a. Transient Cre recombinase expression removed the neo cassette in ES cells. DNase hypersensitivity analysis of mutant cells showed a loss of HS IV, but no disruption of the other hypersensitivity sites. (J:94039)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
