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A Tkneo selection gene flanked by loxP sites inserted in between the tandemly arranged exons 5a and 5b and exon 6 via homologous recombination, disrupting the developmental regulation of alternative splicing between exons 5a and 5b. In homozygous mutants, RT-PCR confirmed that expression of the two isoforms is altered such that the expression of the a isoform is increased and the b isoform is decreased. (J:94005)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
