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Tyrosine residues at positions 175, 195 and 235 (p.Y175F, p.Y195F, p.Y235F), in exons 9-11, respectively, were mutated to phenylalanine residues. Western blot shows that the amount of protein in mutant thymocytes is similar to that of wild-type. A floxed neo was inserted between exons 9 and 10 and subsequently removed by crossing with deleter mice. (J:94074)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
