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A DNA segment encoding a truncated version of bone morphogenic protein receptor, type II (serine/threonine kinase), preceded by an internal ribosome entry site (IRES) and followed by a frt-flanked neomycin resistance cassette, was introduced into the 3' untranslated region of the endogenous tyrosine hydroxylase gene. In situ hybridization and immunohistochemcal analysis revealed reduction in the levels of tyrosine hydroxylase mRNA and protein in brains of homozygous mice. (J:93552)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
