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The transgene comprises a 0.4-kb DNA fragment containing the mouse crystallin, alpha 1 promoter driving expression of the mouse sine oculis-related homeobox 3 homolog (Drosophila) (Six3) protein from a full-length, 1.4-kb cDNA, which is followed by the SV40 intron and polyadenylation signal. Transgenic mRNA is detected from embryonic day 12 (E12.0); its expression was confined to lens fiber cells during the developmental period studied (E12.0 - E13.5) and spatially overlapped that of endogenous Pax6. (J:77351)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
