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Human RET9 cDNA with Y1062F and L985P mutations and a floxed neo were inserted into exon 1 of the endogenous locus. Leucine 985 was at the end of the kinase domain. Mating with mice expressing Cre in the germline excised the neo. RT-PCR showed expression of the mutant allele in brain. (J:93262)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
