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A targeting vector was designed to introduce a p.S389A mutation (T>G) in exon 11. This should abolish phosphorylation of the protein at that amino acid residue in the encoded peptide. A loxP site flanked neomycin resistance gene cassette was introduced downstream of exon 11 and subsequently excised by crossing with Cre expressing deleter mice. Expression of the mutated allele was confirmed by RT-PCR analysis. (J:93328)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
