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A targeting vector was designed to replace exons 3-5 with an in-frame GFP and insert a floxed neo. Crossing with mice expressing Cre recombinase in the germ line removed the neomycin resistance gene. Fluorescence was detectible in virtually all thymocytes of mutant mice. Western blot showed that GFP expression in mutants was similar to that of gene expressed in wild-type mice. (J:93337)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
