The transgene contains the coding sequence, intronic regions, and regulatory elements of the human microtubule-associated protein tau (MAPT) gene. Tg(MAPT)8cPdav integrated on chromosome 7 [104,477,768-104,477,769 ; mm10] in an intron of the tripartite motif-containing 30D locus (Trim30d). The transgene copy number was not calculated. It was not determined if this resulted in any genomic duplication(s) or if this alters endogenous Trim30d expression. (J:85952, J:276927)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Swiss Webster x (C57BL/6 x DBA)F1
--
Insertion, Intergenic deletion
--
1
--
87

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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