A targeting vector was designed to replace an 11kb genomic fragment encompassing the Hmx2 and Hmx3 homeoboxes with a neomycin resistance gene. The only potential protein to be translated would be a truncated Hmx3 protein lacking the C-terminal portion essential for DNA-binding. (J:92940)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129
Targeted
Insertion, Intergenic deletion
--
1
--
1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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