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The transgene contains the human CD8 alpha and beta chain genes driven by the T cell-specific Lck promoter. CD8alpha-alpha homodimers were expressed on 62% of thymocytes and CD8alpha-beta heterodimers on 14% of thymocytes. Peripheral T cells preferentially expressed the CD8alpha-beta heterodimers at a 4:1 ratio. Human CD8alpha was detected on both CD4+ and CD8+ T cells. (J:92994)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
