Log In|Sign Up
EN
A functionally rearranged Tcra gene was used in the construction of this transgene. A recombined Tcra gene with Valpha2.3 and JalphaTA39 gene segments was cloned from the B10.PL hybridoma "172.10". This hybridoma was specific for the 11 amino-terminal residues of myelin basic protein (MBP). Crossing this line with the Tg(TCRB)C14Jg line produces a T cell with a transgenic TCR that has high affinity for the first 11 amino acids of MBP. In these doubly transgenic mice, 50-95% of CD3+ cells expressed the transgenic Tcra gene. (J:92991)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
Show/Hide columns
| Phenotypes |
|---|
References Literature
Title
PMID
Journal
Year
IF
