Exon 1, containing the translational start site of the Pparg1 isoform, and part of exon 2, encoding the first zinc finger of the DNA binding domain, were replaced with a PGK-neo cassette. Both isoform 1 and 2 were disrupted by this event, as shown by lack of protein in Western blot of white adipose tissue. (J:92826)
Basic Information
Insertion, Intragenic deletion
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count