Exon 1, containing the translational start site of the Pparg1 isoform, and part of exon 2, encoding the first zinc finger of the DNA binding domain, were replaced with a PGK-neo cassette. Both isoform 1 and 2 were disrupted by this event, as shown by lack of protein in Western blot of white adipose tissue. (J:92826)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129S2/SvPas
Targeted
Insertion, Intragenic deletion
--
1
10
7

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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