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A minigene encoding human decay accelerating factor for complement (CD55, Cromer blood group system) (DAF) is expressed under control of the promoter of the porcine membrane cofactor protein/CD46, trophoblast-lymphocyte (MCP) gene. Immunohistochemistry revealed high levels of human DAF expression in the vascular endothelia and nerves of all organs examined, as well as on peripheral blood erythrocytes. Splenocytes and erythrocytes resisted lysis by human serum in an expression level-dependent manner, and hearts from transgenic mice functioned longer upon perfusion with human serum than did those of controls. (J:92493)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
