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The transgene contains a mouse Ctla4/Igh-1a fusion cDNA from which a soluble form of the CD152 antigen (CTLA4Ig) is expressed under control of the human keratin 14 (KRT14) enhancer/promoter, which directs expression to basal squamous epithelial cells primarily of the skin, thymus and tongue. Expression is enhanced by inclusion in the construct of most of the human growth hormone gene to provide intronic, 3' non-coding and polyadenylation sequences. Transgenic mice show blood circulating blood levels of CTLA4Ig that are easily detectable by ELISA or functional assays. (J:35353, J:65045)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
