The open reading frame, which lies on a single exon, was replaced with an in frame fusion of lacZ with the sequence encoding the first five residues followed by an FRT site flanked neomycin resistance gene cassette. Mice with and without the neo cassette have the same phenotype. LacZ expression in heterozygous mutant mice recapitulates that of wild-type mice. (J:84077)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129P2/OlaHsd
Targeted
Insertion, Intragenic deletion
--
1
2
12

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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