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EN
The transgene comprises the entire coding sequence of human cytochrome P450, family 4, subfamily b, polypeptide 1 (CYP4B1) cDNA coupled to the 5' flanking region and hepatic control sequence of the human apolipoprotein E gene. Immunoblot analysis of hepatic microsomes from transgenic mice revealed an immunoreactive protein having the mobility of human CYP4B1. Lauric acid omega-hydroxylation was 25% greater and mutagenic activation of 2-aminofluorene two-fold greater in transgenic than in control liver microsomes; both these activities were abrogated by antibodies to CYP4B1. (J:70026)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
