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A cDNA encoding mouse IL2RG lacking the carboxyl-terminal 48 amino acids of the 85-amino acid cytoplasmic domain was inserted into an expression vector containing 5 kb of 5' flanking sequence, including the promoter, transcription initiation site and first intron, and 5.5 kb of 3' flanking sequence including the locus control region (LCR) of the human CD2 gene. The transgene product was found to be expressed on CD4+ CD8+ thymocytes and on splenic and peripheral blood T lymphocytes. (J:92739)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
