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This transgene contains a 14 kb genomic fragment including all of the human DM15 gene and the last exon from the upstream gene DMWD. Two founder lines were generated Tg26 and Tg15 with 25 and 20 copies of the transgene integrated, respectively. Expression is seen in the muscle and smooth muscle containing tissues. Tg26 has a higher level of expression and more severe phenotype compared to Tg15 which has lower expression and a milder version of the same phenotype seen in Tg26. (J:33711)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
