Log In|Sign Up
EN
A lacZ/neo cassette was inserted in frame after the third codon in exon 1, replacing the remainder of exon 1. Southern blot confirmed recombination in mutant mice. Northern blot indicated a lack of full-length transcript in homozygotes, but presence of a lacZ-containing transcript in homozygotes and heterozygotes. Absence of wild-type protein was demonstrated by an immunohistochemistry assay of sciatic nerves and brain from mutants. (J:92517)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
Show/Hide columns
| Phenotypes |
|---|
References Literature
Title
PMID
Journal
Year
IF
