Tg(TNNT2-deltaGlu160)15Imeg

The transgene encodes a mutant human troponin T2, cardiac having a single-codon, in-frame deletion of the glutamic acid at amino acid position 160. This mutation was identified in affected members of families having dominantly inherited left ventricular hypertrophic cardiomyopathy which, although often mild or subclinical, is associated with a high incidence of sudden death at an early age. (J:91746)