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A truncated dominant negative form of the Jun transcription factor is expressed by this transgene. Transcription is directed by a tetracycline-responsive promoter element (TRE). When bred with another transgenic mouse expressing tetracycline-controlled transactivator protein (tTA) to create a bitransgenic animal, Fosb expression can be negatively regulated with the tetracycline analog, doxycycline. (J:83308)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
