The neo cassette was removed via partial cre recombination leaving loxP sites surrounding exon 2, which encodes slightly more than five of the seven transmembrane-spanning domains. Recombination in mutant mice was confirmed by Southern blot and PCR. (J:92301)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count