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Exons 44 to 47, encoding the kinase domain, were replaced by an IRES-Betageo-pA cassette. Northern blot of heterozygous ES cells showed reduced expression and detected a larger transcript, corresponding to the fusion of Frap1 to Betageo. Western blot showed that protein levels were also reduced. (J:92252)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
