The protein-coding region containing the pro-, metalloprotease, disintegrin and cysteine rich domains were replaced with a neo via homologous recombination. Northern blot of mutant testes indicated lack of transcript and Western blot of testicular germ cells of mutants showed complete absence of the precursor form of the protein. (J:92271)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129S2/SvPas
Targeted
Insertion, Intragenic deletion
--
1
--
2

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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