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Transgenic mice overexpress the simian plasma cholesteryl ester transfer protein under control of the mouse metallothionein (MT1) promoter. Four lines were characterized with mice exhibiting a negative correlation between plasma CETP activity and total plasma cholesterol, plasma apolipoprotein A-I levels (APOA1), and plasma APOAI to APOB ratio. This line, UCTP-20, was the highest expressor of the transgene and was selected for further study. Significant transgene expression was detected by Northern blotting in the liver, brain and heart. (J:92448)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
