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Exon 1 was replaced by a neomycin resistance gene in the targeting construct. Southern blot and PCR confirmed recombination in mutant mice and Western blot indicated gene expression was reduced in heterozygotes and completely lost in homozygous mutants. (J:90889)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
