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A neomycin resistance gene replaced part of the 5' upstream promoter, exon 1 and part of intron 1, including the AUG start codon, 106 additional codons and a 5' UTR of at least 145 nucleotides. Northern blot indicated absence of transcript in brains of mutant mice. Further confirmation was provided by Western blot analysis showing lack of wild-type protein in brains of mutant mice. (J:91889)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
