Part of the first exon and first intron was replaced by a lacZ-neomycin fusion gene, such that beta-galactosidase should be expressed under the control of the endogenous promoter. Northern and western blot analysis demonstrated an absence of encoded mRNA and protein, respectively, in homozygous mice. (J:55800)
Basic Information
(129X1/SvJ x 129S1/Sv)F1-Kitl+
Insertion, Intragenic deletion
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count