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This allele involved the use of an embryonic stem cell line with a Hoxd11/lac/loxP reporter gene inserted 5' of Hoxd13. A floxed neo was inserted 3' to the Hoxd1 gene in the reverse orientation. Crossing with mice in which Cre is expressed in the germ line excised the neo and reversed the orientation of the larger floxed sequence. (J:91567)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
