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This transgene contains the MMTV (mouse mammary tumor virus) LTR promoter, a 4.6 kb cDNA from the rat Erbb2 (avian erythroblastosis B2) oncogene, and an SV40 polyadenylation site sequence. The activated form of the rat gene is used in this construct, which differs from the wild-type allele by a point mutation, Val664Glu. Non-uniform and random transgene expression is detected by RNase protection assay in mammary gland epithelium from hemizygous transgenic mice. Six transgenic lines were produced (NA, NB, NF, NK, NL and NM). (J:48632)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
