The coding sequence in exon 1 and 4 kb of sequence including exons 2-4 were replaced with a floxed Dsred-FRT-puro-pA cassette, Pax7 cDNA and an FRT flanked IRESnlacZ cassette. The splice donor site was deleted to ensure that no functional Pax3 protein could be made. Southern blot confirmed recombination. (J:90568)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129S2/SvPas
Targeted
Insertion, Intragenic deletion
--
1
8
1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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