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The transgene comprises the entire early coding sequence from wild-type human papillomavirus 16 (HPV16), extending from nucleotide (nt) 97 through nt 6152, flanked upstream by approximately 2 kilobases of DNA including the promoter/enhancer of the human keratin 14 (epidermolysis bullosa simplex, Dowling-Meara, Koebner) gene and downstream by 500 base pairs derived from the 3' untranslated sequence of the same gene, including its polyadenylation signal. The keratin 14 promoter drives expression of the transgene in basal cells of the squamous epithelium. (J:20125)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
