Log In|Sign Up
EN
The targeting construct contained 6.0 kb of the upstream region and the entire coding region of the human transthyretin gene. The coding sequence contained a methionine to valine substitution mutation at position 30. Transgenic transthyretin transcript was detected in liver, brain, kidney, and yolk sac. In some cases aberrant transcript that was larger than normal transcript was detected. (J:91391)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
Show/Hide columns
| Phenotypes |
|---|
References Literature
Title
PMID
Journal
Year
IF
