Log In|Sign Up
EN
Polgtm1Lrsn mice were mated with ubiquitously expressing Flp-mice to excise the Frt-flanked neo, leaving exon 3 flanked with loxP sites and an aspartic acid to alanine codon change at 257, in the second exonuclease domain. Biochemical assays revealed a profound reduction in exonuclease activity in these mutants. (J:91077)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
Show/Hide columns
| Phenotypes |
|---|
References Literature
Title
PMID
Journal
Year
IF
