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Point mutations were introduced into the core sequence of all 4 CTCF binding sites resulting in five G-to-T, two C-to-A, one (G/A)-to-T, and one-(T/C)-to-G conversions at each site. A single loxP site was also present after excision of a floxed neomycin resistance gene cassette. EMSA analysis confirmed that these mutated CTCF binding sites are unable to bind CTCF. (J:91020)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
